Blueprint Protocol (Bryan Johnson)
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The most extensively-documented self-experiment in longevity practice: a publicly-published daily protocol of meal timing, supplements, exercise, sleep prescription, and clinical interventions (rapamycin, plasma exchange, gene therapy attempts, and others, with periodic protocol changes). What the n=1 evidence does and doesn’t establish; what is widely-adopted-derivable from the protocol versus what is idiosyncratic to Johnson; the “Don’t Die” rhetorical posture distinguished from the underlying protocol.