Hormone Replacement Therapy (Female: HRT/BHRT)
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Estradiol and progesterone (with or without testosterone) for perimenopause, menopause, and post-menopausal symptom and risk management. The WHI re-evaluation, the timing-hypothesis literature, and the current Menopause Society / ACOG guidelines; the bioidentical-vs-conjugated distinction; the candidate-vs-non-candidate framing (breast-cancer history, thrombosis risk, late initiation).